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U.S. Study Finds Lower Carcinogen Exposure After Switching from Smoking to Vaping

In a collaboration between California State University San Marcos and Brown University, researchers conducted a randomized trial comparing harmful substance exposure from smoking and vaping. Dr. Nikki Nollen, co-leader of the Cancer Prevention and Control
In a collaboration between California State University San Marcos and Brown University, researchers conducted a randomized trial comparing the harmful differences between smoking and vaping. <\/div>
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Dr. Nikki Nollen, co-leader of the Cancer Prevention and Control Research Program at the KU Cancer Center, served as the principal investigator on site. <\/div>
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Dr. Nollen stated, “E-cigarettes contain high concentrations of nicotine and other appealing fruity flavors that may help transition smokers to tobacco sticks and reduce their potential health risks.” “We wanted to examine the biomarkers of exposure in both groups and determine if the risks of e-cigarettes are lower than those of combustible cigarettes.”<\/span><\/div>
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Participants were adult smokers who had smoked at least 5 cigarettes daily for at least 25 days in the past 30 days and had been smoking for at least 6 months before switching to e-cigarettes. Data was collected and analyzed between September 18, 2019, and September 4, 2020. <\/div>
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According to the study summary, participants were provided with a 6-week supply of preferred flavored vaping products (with a nicotine content of 5%) along with brief education, training, and action plans to completely transition from combustible cigarettes to e-cigarettes. The control group was instructed to continue smoking as usual. <\/div>
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A reduction in the analyzed biomarkers was determined. <\/div>
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The compiled data indicated a reduction in the analyzed biomarkers. “The primary outcome was a decrease in the concentration of urine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) at week 6. Secondary outcomes included changes in cotinine levels in urine, expired carbon monoxide (CO), respiratory symptoms, lung function, blood pressure, the consumption of combustible cigarettes in the past 7 days, and the transition rates at weeks 2 and 6 (only for the e-cigarette group).”<\/span><\/div>
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Nollen noted that the levels of reduction in certain parameters were surprising. “Compared to the control group that continued to smoke as usual, their NNAL decreased by 64%, CO decreased by 47%, and respiratory symptoms decreased by 37%.”<\/span><\/div>